it finally occurred to somebody to use mathematics / modelling: Daniel Nichol, Peter Jeavons, Alexander G. Fletcher, Robert A. Bonomo, Philip K. Maini, Jerome L. Paul, Robert A. Gatenby, Alexander R.A. Anderson, Jacob G. Scott. Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. PLOS Computational Biology, 2015; 11 (9): e1004493 http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.100449... will it work? -- Warren D. Smith http://RangeVoting.org <-- add your endorsement (by clicking "endorse" as 1st step)