Re: [math-fun] J Borwein's sig
From the article in the nih.gov link below: "The *** E. coli *** strains used in this study and their relevant genotype are detailed in Supplementary Table S1." http://en.wikipedia.org/wiki/Escherichia_coli "The first complete DNA sequence of an E. coli genome ... was published in 1997. It was found to be a *** circular *** DNA molecule 4.6 million base pairs in length, containing 4288 annotated protein-coding genes (organized into 2584 operons), seven ribosomal RNA (rRNA) operons, and 86 transfer RNA (tRNA) genes." E. coli has *** circular *** DNA. Human nuclear (non-mitochondrial) DNA isn't circular. At 09:41 AM 12/28/2012, Michael Kleber wrote:
On Fri, Dec 28, 2012 at 11:56 AM, Henry Baker <hbaker1@pipeline.com> wrote:
I don't know what % of the time (human nuclear--i.e., non-mitochondrial)
DNA spends doing recombination, but I would guess/hope very small. During the rest of the time, it is my understanding that there aren't any knots in this DNA.
I'm sorry, I didn't realize we were still arguing about this question of fact. Let me re-post the link from up-thread, along with the beginning of the article this time.
http://www.ncbi.nlm.nih.gov/pubmed/22187153 "Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication"
Henry is perhaps thinking of the work of Harvard Fellow Erez Lieberman. He claims that human nuclear DNA folds into something he calls a fractal globule which has few if any knots. http://www.aaas.org/news/releases/2011/1201sp_ge_prize.shtml I hear him speak on this in April, but I don't recall the details --only that he had some beautify simulations of DNA folding and unfolding. On Fri, Dec 28, 2012 at 1:07 PM, Henry Baker <hbaker1@pipeline.com> wrote:
From the article in the nih.gov link below:
"The *** E. coli *** strains used in this study and their relevant genotype are detailed in Supplementary Table S1."
http://en.wikipedia.org/wiki/Escherichia_coli
"The first complete DNA sequence of an E. coli genome ... was published in 1997. It was found to be a *** circular *** DNA molecule 4.6 million base pairs in length, containing 4288 annotated protein-coding genes (organized into 2584 operons), seven ribosomal RNA (rRNA) operons, and 86 transfer RNA (tRNA) genes."
E. coli has *** circular *** DNA. Human nuclear (non-mitochondrial) DNA isn't circular.
At 09:41 AM 12/28/2012, Michael Kleber wrote:
On Fri, Dec 28, 2012 at 11:56 AM, Henry Baker <hbaker1@pipeline.com> wrote:
I don't know what % of the time (human nuclear--i.e., non-mitochondrial)
DNA spends doing recombination, but I would guess/hope very small. During the rest of the time, it is my understanding that there aren't any knots in this DNA.
I'm sorry, I didn't realize we were still arguing about this question of fact. Let me re-post the link from up-thread, along with the beginning of the article this time.
http://www.ncbi.nlm.nih.gov/pubmed/22187153 "Topo IV is the topoisomerase that knots and unknots sister duplexes during DNA replication"
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